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Clinical Practice

Artificial intelligence in clinical care, deployment, and regulation.

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Color key: News and Events

More than 950,000 US clinicians submitted over 270 million queries to an AI clinical information platform over 2.5 years, mostly about treatment decisions [2]. Several items address oversight of such tools.

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One study examines how well electronic health record developers comply with federal requirements to disclose AI risks [6], and lobbying groups are working behind the scenes to influence how states regulate medical AI [5]. AEGIS, a framework for post-market governance of adaptive medical AI, targets US and EU requirements [15]. Separately, a study finds that prompt wording effects vary by model, which challenges reliable deployment of medical language models [13].

Also this week: the list includes six items on safety and evaluation, three each on decision support and documentation, and two on imaging, including FedFound, a GI endoscopy model trained across institutions without pooling patient data. One small epilepsy study reported about 80% fewer seizure-detector false alarms.

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The picture as of October 19, 2026; numbered links go to the items below.

JMIR AIOctober 15, 2026
Toward a Living Meta-Framework for Evaluating Generative AI in Mental Health

A JMIR AI paper argues that fragmented frameworks for evaluating generative AI in mental health need a shared, continuously updated meta-framework to support safety and regulatory clarity.

PubMed AI in medical educationOctober 15, 2026
Clinician Use of an Artificial Intelligence-Enabled Clinical Information Platform

Over 2.5 years, more than 950,000 US clinicians submitted over 270 million queries to an AI clinical information platform, mostly about treatment decisions.

npj Digital MedicineOctober 15, 2026
TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection

npj Digital Medicine describes TrajOnco, a multi-agent language model framework that reasons over longitudinal electronic health records to support multi-cancer early detection.

npj Digital MedicineOctober 15, 2026
An artificial intelligence framework for end-to-end rare disease phenotyping from clinical notes using large language models

A peer-reviewed npj Digital Medicine paper presents a large language model framework that extracts rare disease phenotypes observable clinical features from clinical notes from start to finish.

STAT News AIOctober 14, 2026
STAT+: Lobbyists and trade groups fight to shape how states regulate medical AI

Reports that physician and hospital lobbying groups and trade associations are working behind the scenes to influence how states regulate artificial intelligence in medicine.

npj Digital MedicineOctober 14, 2026
Electronic health record developer adherence to federal AI risk transparency requirements

Study examines how well electronic health record developers comply with federal requirements to disclose risks of the artificial intelligence tools embedded in their products.

npj Digital MedicineOctober 14, 2026
From research to clinical practice: Expert consensus on Neuroimaging AI tools for the Memory clinic (Neuro-AIM)

Expert consensus statement on how artificial intelligence tools for neuroimaging should move from research into routine use in memory clinics that evaluate dementia.

npj Digital MedicineOctober 14, 2026
FedFound: Federated Foundation Model for GI endoscopy imaging

FedFound is a foundation model for gastrointestinal endoscopy imaging trained with federated learning, which lets multiple institutions train a shared model without pooling patient data.

Nature MedicineOctober 14, 2026
Making AI work in healthcare

A Nature Medicine issue examines challenges and lessons learned from deploying artificial intelligence models into healthcare across diverse clinical settings.

JMIR Medical InformaticsOctober 13, 2026
Ambient AI Scribe Technology and Perceived Documentation Efficiency Among Surgeons: Cross-Sectional Study

A cross-sectional study of surgeons examines how ambient AI scribe technology, which records patient-clinician conversations to draft notes, relates to perceived documentation efficiency and burden.

JMIR Medical InformaticsOctober 13, 2026
Automating Injury Severity Score Calculation From Free-Text Discharge Diagnoses Using Domain-Specific Retrieval-Augmented Large Language Models: Retrospective Validation Study

A retrospective validation study tests retrieval-augmented large language models for automatically calculating Injury Severity Scores from free-text discharge diagnoses to support trauma registries.

npj Digital MedicineOctober 13, 2026
Realizing the value of the divergence event in clinical human-AI interaction

A commentary argues that when a clinician and an AI system disagree, current interfaces record only the outcome, and proposes ways to make that divergence visible and useful.

npj Digital MedicineOctober 13, 2026
Model-dependent prompt effects challenge reliable deployment of medical LLMs in traditional Chinese medicine

A study in npj Digital Medicine finds that the effect of prompt wording varies by model, which challenges reliable deployment of medical large language models in traditional Chinese medicine.

Nature MedicineOctober 13, 2026
Human, artificial intelligence collaboration for comanaging epilepsy in real time

A small Nature Medicine study lets epilepsy patients chat with their EEG electroencephalography monitoring through a language-model interface; patient feedback cut seizure-detector false alarms by about 80% without clinician input.

npj Digital MedicineOctober 13, 2026
AEGIS: an operational infrastructure for post-market governance of adaptive medical AI under US and EU regulatory frameworks

npj Digital Medicine describes AEGIS, an operational framework for post-market governance of adaptive medical AI systems under United States and European Union regulatory requirements.